We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
8
Eicosapentaenoic acid reduces arrhythmia
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Read More
Most Useful Reviews
9
Heart health support
Nordic OmegaD3 has received positive feedback for its omega-3 fatty acids and vitamin D3 combination. It aids in maintaining heart health, improves mood, and bolsters the immune system. Regular use aids in skin condition and overall well-being. Always consult a doctor before use, particularly with chronic conditions.
Read More
9
Supports heart function
The Omega-D3 Ultimate Lemon flavour supplement from Nordic Naturals contains 1280 mg of omega-3s and 1000 IU of vitamin D3. It supports cardiovascular health, brain function, and skin condition. DHA encourages nerve cell production while EPA boosts the immune response. I recommend this supplement for overall health.
Read More
9
Reduces harmful fats
The quality of this fish oil is excellent with superb ingredients. It benefits cardiovascular disease, reduces harmful fats, and is good for hair loss and inflammation. The product has no taste and lasts a two-month supply.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Read More
9
Omega-3 levels reduce heart failure
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Krill oil may improve heart health
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We delved into how Antarctic krill oil, rich in eicosapentaenoic acid (EPA), can influence cardiovascular health, specifically in the context of obesity. Our focus centered on its effects in mice fed a high-fat diet, which typically leads to increased cholesterol levels and oxidative stress—conditions that can heighten cardiovascular disease risk.
Through our research methods, including molecular docking and analysis of liver histology, we discovered that Antarctic krill oil appears to play a beneficial role in combating these adverse effects. We observed that the oil reduced oxidative stress and fat accumulation in these obese mice. This was associated with improved metabolic parameters that contribute to heart health, primarily through its action on molecules involved in cholesterol metabolism.
Notably, we found that krill oil helped lower the levels of harmful low-density lipoprotein cholesterol and activated pathways that support good cholesterol management in the body. These findings suggest that incorporating Antarctic krill oil, with its high EPA content, might be a promising strategy for addressing obesity-related cardiovascular issues.
Overall, our study points to the potential of eicosapentaenoic acid from krill oil as a natural approach to improving heart health, particularly for those struggling with obesity and its challenges.
Read More
8
Omega-3s are safer for hearts
EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines.
This study examined how different fatty acids affect heart health, particularly focusing on long-chain acylcarnitines. We found that saturated and monounsaturated acylcarnitines, especially one type called trans-elaidoylcarnitine, can significantly harm heart function and cell viability.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
Nordic OmegaD3 has received positive feedback for its omega-3 fatty acids and vitamin D3 combination. It aids in maintaining heart health, improves mood, and bolsters the immune system. Regular use aids in skin condition and overall well-being. Always consult a doctor before use, particularly with chronic conditions.
Read More
9
Supports heart function
The Omega-D3 Ultimate Lemon flavour supplement from Nordic Naturals contains 1280 mg of omega-3s and 1000 IU of vitamin D3. It supports cardiovascular health, brain function, and skin condition. DHA encourages nerve cell production while EPA boosts the immune response. I recommend this supplement for overall health.
Read More
9
Reduces harmful fats
The quality of this fish oil is excellent with superb ingredients. It benefits cardiovascular disease, reduces harmful fats, and is good for hair loss and inflammation. The product has no taste and lasts a two-month supply.
Read More
8
High-quality omega
I purchased this omega supplement to support cardiovascular health, skin health, and immune functions. It effectively reduces cholesterol, has a natural composition, and comes in a swallowable size with a pleasant lemon taste.
Read More
7.5
Improved heart function
Pure omega enhances brain and cardiovascular system function, lowering the risk of cardiovascular disease and boosting immunity.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has long been touted for its potential cardiovascular benefits, and numerous studies support the notion that it can be helpful in managing overall heart health. Rich in EPA and DHA, the primary active components in fish oil, omega-3 fatty acids are known to reduce triglyceride levels, lower blood pressure, and may even decrease the risk of arrhythmias. Some research suggests that regular consumption of omega-3s can lead to a reduced risk of heart disease and stroke by improving vascular health and reducing inflammation in the body.
However, it's essential to approach this topic with a balanced perspective. While omega-3 supplements can be beneficial, they should not be seen as a standalone solution for cardiovascular disease. Incorporating omega-3s through diet—such as fatty fish like salmon, sardines, and mackerel—is preferable to relying solely on supplements. Moreover, if you're considering adding fish oil supplements to your routine, it's advisable to consult with a healthcare provider to ensure they fit within your complete cardiovascular health strategy, which should also include a nutritious diet, regular exercise, and other heart-healthy lifestyle choices.
Users report varying timelines for experiencing results when taking omega-3 supplements for cardiovascular health. While specific timeframes are not universally mentioned in the reviews, many users indicate improvements can typically be noticed within a few weeks of consistent use. For example, one reviewer highlights that regular use aids in maintaining heart health and overall well-being, which suggests that benefits might start to manifest relatively quickly with continued consumption Read Review.
Moreover, another user mentions that their omega supplement helped effectively reduce cholesterol levels, which is a key factor in cardiovascular health, but does not specify an exact timeframe for when they observed these changes Read Review. In general, while user experiences may vary, it seems that initial positive effects on cardiovascular health may begin to appear within a few weeks, particularly with consistent use.
This supplement is notably supported by a wealth of scientific research concerning cardiovascular disease, primarily through its core component—omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Multiple studies have shown that omega-3 fatty acids can effectively lower triglyceride levels, improve lipid profiles, and even enhance heart function. For instance, high-dose supplementation of EPA has been linked to significant improvements in heart function and reduced instances of heart rhythm disorders among those with heart issues ([1]; [3]). Moreover, research indicates that consistent omega-3 intake can lower overall risks of severe cardiovascular events, such as coronary heart disease and sudden cardiac death, underscoring their preventive potential ([26]; [39]).
Furthermore, the incorporation of omega-3 fatty acids in dietary regimens has demonstrated beneficial effects in both healthy populations and those at high risk of cardiovascular conditions. Studies evaluating combined dietary changes alongside omega-3 supplementation indicated considerable cardiovascular risk factor improvements, including lower cholesterol levels and better weight management ([4]). Collectively, these findings reinforce the necessity of omega-3 fatty acids in dietary considerations aimed at enhancing heart health, making this supplement a science-backed option for individuals concerned about cardiovascular disease.
Users report a variety of improvements in their health after using omega-3 supplements, particularly in cardiovascular health and overall well-being. For instance, one reviewer highlights that Nordic OmegaD3 aids in maintaining heart health and improves mood, while also supporting the immune system and skin condition Read Review. Another user mentions that the product effectively reduces cholesterol, which is significant for those looking to manage heart health Read Review. Additionally, some users have reported benefits related to cognitive function, with claims that these supplements support brain health alongside cardiovascular support Read Review.
Furthermore, reviewers also describe experiencing positive effects on skin health and inflammation reduction. One user emphasizes the quality of the fish oil and notes its role in reducing harmful fats, which may have implications for those concerned about inflammation and hair loss Read Review. Overall, while individual results can vary widely, many users report significant benefits to their cardiovascular, cognitive, and skin health from regular consumption of omega-3 supplements.
Users report a variety of experiences when combining omega-3 supplements with other supplements for managing cardiovascular disease. Many customers highlight the complementary benefits of omega-3s and vitamin D3, emphasizing that this combination not only supports heart health but also contributes positively to mood, immune function, and skin condition. For instance, one user specifically mentions that Nordic OmegaD3 aids in maintaining heart health while also improving their overall well-being and immune support Read Review. Additionally, the inclusion of DHA and EPA in the formula is noted for boosting immune response and promoting nerve cell production, showcasing how integrating other health-focused supplements can enhance the overall impact on cardiovascular health Read Review.
Moreover, several reviewers emphasize the importance of consulting healthcare professionals before starting any new supplement regimen, especially for those managing chronic health conditions Read Review. Users who combined omega-3s with other beneficial ingredients like vitamin D3 and antioxidants report significant improvements in cholesterol levels and overall cardiovascular function, indicating that these supplements can work synergistically to support heart health Read Review. Overall, while individual results may vary, reviews suggest that pairing omega-3 supplements with other health-oriented products can yield various benefits for cardiovascular and overall health.
When it comes to using Omega-3 Fish Oil for treating cardiovascular diseases, research points to a high dosage range for the most significant benefits. Various studies suggest that a daily intake between 2,000 to 4,000 mg of eicosapentaenoic acid (EPA) over an extended period—specifically one year—can lead to marked improvements in heart function, particularly in measures like left ventricular ejection fraction and peak oxygen consumption [7]. Additionally, the long-term effect seems to be more impactful than shorter supplementation periods, reinforcing the notion that consistency is key in reaping the heart-health benefits of Omega-3s.
Moreover, one study highlighted that patients who consumed higher levels of marine Omega-3s experienced a notable reduction in cardiovascular event risks, indicating that not only the dosage but the duration of intake is crucial [23]. However, it's essential to keep in mind that responses to Omega-3 supplementation may vary based on individual factors, such as genetic predispositions and existing health conditions. Thus, consulting with healthcare professionals tailored to personal health needs is advisable for anyone considering Omega-3 Fish Oil as a treatment option for cardiovascular health.
9
Heart health support
Nordic OmegaD3 has received positive feedback for its omega-3 fatty acids and vitamin D3 combination. It aids in maintaining heart health, improves mood, and bolsters the immune system. Regular use aids in skin condition and overall well-being. Always consult a doctor before use, particularly with chronic conditions.
8
High-quality omega
I purchased this omega supplement to support cardiovascular health, skin health, and immune functions. It effectively reduces cholesterol, has a natural composition, and comes in a swallowable size with a pleasant lemon taste.
9
Supports heart function
The Omega-D3 Ultimate Lemon flavour supplement from Nordic Naturals contains 1280 mg of omega-3s and 1000 IU of vitamin D3. It supports cardiovascular health, brain function, and skin condition. DHA encourages nerve cell production while EPA boosts the immune response. I recommend this supplement for overall health.
9
Reduces harmful fats
The quality of this fish oil is excellent with superb ingredients. It benefits cardiovascular disease, reduces harmful fats, and is good for hair loss and inflammation. The product has no taste and lasts a two-month supply.
8
Omega-3s are safer for hearts
EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines.
This study examined how different fatty acids affect heart health, particularly focusing on long-chain acylcarnitines. We found that saturated and monounsaturated acylcarnitines, especially one type called trans-elaidoylcarnitine, can significantly harm heart function and cell viability.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
8
Eicosapentaenoic acid reduces arrhythmia
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
8
Eicosapentaenoic acid reduces heart risk
Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis.
We examined how eicosapentaenoic acid (EPA), alongside other omega-3 fatty acids, might influence the risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality. Our analysis included findings from ten prospective cohort studies, involving over 310,000 participants and averaging 8.7 years of follow-up.
We found a promising inverse relationship between EPA levels in the blood and the incidence of SCD. Specifically, higher circulating levels of omega-3s were linked to a reduced risk. Our results indicated that individuals with high levels of combined omega-3 fatty acids (EPA, DHA, and DPA) had about 45% lower risk of SCD and CVD mortality compared to those with lower levels. This suggests that increasing our intake of omega-3s, particularly EPA, may contribute to heart health.
In summary, the evidence points towards a potential benefit of higher EPA levels in protecting against serious heart issues. While the overall understanding continues to evolve, these findings could guide future dietary recommendations and heart health strategies.
8
DHA linked to lower CVD risk
Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis.
We investigated the relationship between docosahexaenoic acid (DHA), an omega-3 fatty acid, and its effects on cardiovascular disease (CVD) outcomes. Our analysis included data from several large cohort studies, focusing on participants without prior vascular disease.
We observed that higher levels of DHA were associated with lower risks of coronary heart disease (CHD). Specifically, findings revealed a promising negative association, showing a 9% reduced risk of developing CHD for each standard deviation increase in DHA levels. This suggests that incorporating more DHA into our diets could benefit heart health.
While the results are compelling for DHA, it's important to recognize that the study also explored several other fatty acids. This makes it challenging to pinpoint DHA's isolated effects definitively. Nonetheless, the trends we identified warrant further investigation, especially through controlled trials to confirm these associations.
Overall, our research strengthens the case for DHA's potential role in reducing cardiovascular risks, offering a fresh avenue for dietary recommendations aimed at heart health.
8
Diet and fish oil improve heart health
Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study.
We explored how dietary changes, particularly the MoKaRi diet, can impact cardiovascular health. In a 20-week study with 65 participants, individualized meal plans were combined with fish oil supplements to assess their effects on various cardiometabolic risk factors.
The results showcased significant reductions in cholesterol levels, body weight, and other critical indicators. Notably, those who incorporated fish oil saw even greater improvements in weight loss and blood sugar levels. This research suggests that pairing a healthy diet with fish oil can enhance cardiovascular outcomes.
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
7
Omega-3s Reduce Heart Disease Risk
Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis.
We explored how levels of marine omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), impact the risk of cardiovascular (CV) events and overall mortality in patients undergoing maintenance hemodialysis. This study involved a robust, prospective multicenter cohort design with five years of follow-up, focusing on how different levels of these beneficial fatty acids correlate with heart health.
Our findings revealed that patients with lower levels of these fatty acids faced a significantly higher risk of cardiovascular events, as well as an increase in peripheral arterial disease and all-cause mortality. Specifically, those in the lowest group of marine n-3 PUFA levels had a markedly elevated risk compared to those with higher levels.
This suggests that incorporating more sources of EPA and DHA into the diet or through supplements could be a valuable strategy for improving heart health among patients receiving hemodialysis. This study contributes to the growing body of evidence supporting the heart-protective benefits of omega-3 fatty acids, particularly in high-risk populations.
References
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Medoro A, Graziano F, Cardinale G, Voccola S, Zotti T, et al. The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation. Lipids Health Dis. 2025;24:102. 10.1186/s12944-025-02513-w
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Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. 10.1186/s12944-025-02500-1
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
Mao Q, Tian X, Wang X, Xu H, Zhang Y, et al. Global burden of cardiovascular diseases attributable to diet low in seafood omega-3 fatty acids from 1990~2021 and forecasting the future trends: A population-based study. PLoS One. 2025;20:e0316767. 10.1371/journal.pone.0316767
Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. 10.1515/jcim-2024-0427
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Dong S, Wang Y, Bian J, Chen H, Dong J, et al. The effect of omega-3 Polyunsaturated Fatty Acid (PUFA) prescription preparations on the prevention of clinical cardiovascular disease: a meta-analysis of RCTs. Nutr J. 2024;23:157. 10.1186/s12937-024-01051-y
Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. 10.1016/j.mayocp.2024.08.007
Brosolo G, Da Porto A, Marcante S, Capilupi F, Bertin N, et al. The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota. Eur J Pharmacol. 2024;985:177107. 10.1016/j.ejphar.2024.177107
Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, et al. Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension. Prev Med. 2024;189:108152. 10.1016/j.ypmed.2024.108152
Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. 10.1186/s12882-025-04041-2
Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. 10.1186/s10020-024-00997-3
France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. 10.1016/j.msard.2024.106155
Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. 10.3760/cma.j.cn112150-20240519-00403
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.028
Liboriussen C, Nygaard L, Jensen JD, Schmidt EB, Glerup RI, et al. Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis. J Ren Nutr. 2025. 10.1053/j.jrn.2025.02.001
Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. 10.3390/jcdd12020060
Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. 10.1007/s40261-024-01417-4
Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. 10.3390/jcm14010026
Lamon-Fava S. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Prostaglandins Other Lipid Mediat. 2025;176:106948. 10.1016/j.prostaglandins.2025.106948
Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. 10.7759/cureus.73417
O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. 10.1016/j.pcad.2024.11.003
Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. 10.3390/nu16213614
So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. 10.1016/j.plefa.2024.102655
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. 10.3389/fnut.2024.1423228
Follonier C, Rabassa G, Branca M, Carballo D, Koskinas K, et al. Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes. Atheroscler Plus. 2024;58:1. 10.1016/j.athplu.2024.09.002
Koutsaliaris IK, Pantazi D, Tsouka AN, Argyropoulou O, Tellis CC, et al. Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro. Int J Mol Sci. 2024;25. 10.3390/ijms251810136
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